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Changes in Fat Cells May Pave Way for Type 2 Diabetes

http://www.businessweek.com

May result in the 'hyperinflammation' seen in the disease, researchers say. Cellular changes in fat tissue play a major role in the development of type 2 diabetes, a new study shows. University of Cincinnati researchers found that these changes in fat cells -- not the immune system, as previously thought -- are linked to the "hyperinflammation" seen in obesity-related glucose intolerance and type 2 diabetes. The findings, they said, may eventually lead to the development of new drugs to treat type 2 diabetes and may also offer insights into the formation of aggressive cancers. "This finding is quite novel because current drug development efforts target immune cells (macrophages, T-cells) to eliminate this hyperinflammation," said Jorge Moscat, the study's principal investigator and chair of UC's cancer and cell biology department, in a university news release. "Our research suggests obesity-related glucose intolerance has nothing to do with the immune system. It may be more effective to target (fat cells)." In laboratory animals, the researchers found that a gene known as protein kinase C (PKC)-zeta plays a dual role in molecular signaling associated with inflammation. Obesity

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Changes in Fat Cells May Pave Way for Type 2 Diabetes